At a dose equivalent to 1 gram/kilogram of body weight per day, tumors on mice were 100% inhibited, resulting in complete regression of the tumors. Control groups confirmed that tumor growth was not inhibited in the absence of Hypsizygus tessulatus extract. No studies in humans were reported.
Two commercial variations, both originating from Japan, are known:
Buna-shimeji (ja:ブナシメジ), wild type brown coloration. Known as brown beech mushroom, beech mushroom, brown clamshell mushroom;
Bunapi-shimeji (ja:ブナピー) is a white UV-induced mutant of the former, known as white beech mushroom, white clamshell mushroom. The original strain is registered by Hokto Corporation.